In vitro studies suggest Dihexa is approximately 7-10 times more potent than BDNF at inducing synapse formation, with additional advantages of oral bioavailability and blood-brain barrier penetration. Unlike BDNF, Dihexa works through HGF/c-Met rather than TrkB pathways.
Comparative studies demonstrate Dihexa's superior synaptogenic efficacy results from both potent receptor activation and favorable pharmacokinetic properties.