Clinical protocols for DSIP typically use 100-500mcg administered subcutaneously or intramuscularly 30-60 minutes before bedtime, with most studies showing efficacy at 200-300mcg for chronic insomnia. Initial protocols often start at 100mcg for 3-5 days to assess tolerance before increasing to therapeutic levels. Advanced users may employ a loading phase of 500mcg for 5-7 days followed by 200-300mcg maintenance dosing.
PubMed: DSIP dosing studies