Yes, GH-releasing peptides (CJC-1295, Ipamorelin, Sermorelin) should be administered during fasted states as elevated glucose and insulin blunt growth hormone response. Wait at least 2-3 hours after meals and avoid eating for 30-60 minutes after injection. Research from
Journal of Clinical Investigation demonstrates hyperglycemia and hyperinsulinemia significantly reduce peptide-induced GH secretion, with optimal responses occurring during metabolic fasting states.