Most peptide stacks are used continuously for 3-6 month cycles followed by 1-3 month breaks to prevent receptor desensitization. GH-releasing peptides particularly benefit from cycling to maintain pituitary responsiveness. Healing peptides like BPC-157 and TB-500 are often used continuously until the injury resolves. Research in
Endocrine Reviews suggests periodic breaks maintain long-term efficacy and reduce adaptation to exogenous peptide signaling.