Most protocols use 3-6 months on followed by 1-3 months off to prevent receptor desensitization, particularly for GH-releasing peptides. Healing peptides (BPC-157, TB-500) can be used continuously until injury resolution without cycling. Some users taper doses by 25-50% during the final 2 weeks before stopping completely. Research from
Hormone Research suggests periodic breaks maintain pituitary responsiveness and prevent downregulation of endogenous signaling.